Mechanisms contributing to short- and long-term sensitization in Aplysia
Read Online

Mechanisms contributing to short- and long-term sensitization in Aplysia

  • 844 Want to read
  • ·
  • 88 Currently reading

Published .
Written in English


  • Aplysia.,
  • Gastropoda.

Book details:

Edition Notes

StatementWilliam Nelson Frost.
The Physical Object
Paginationvi, 166 leaves, bound.
Number of Pages166
ID Numbers
Open LibraryOL15205271M

Download Mechanisms contributing to short- and long-term sensitization in Aplysia


We have used the gill and siphon withdrawal reflex of Aplysia to study the morphological basis of the persistent synaptic plasticity that underlies long-term sensitization. One critical locus for storage of the memory for sensitization is the set of monosynaptic connections between identified siphon sensory neurons and gill and siphon motor by: The same mechanisms that mediate short-term sensitization underlie long-term sensitization. During long-term sensitization, however, this circuitry is affected for up to several weeks. The duration of this form of plasticity is evidently due to changes in gene expression and thus protein : Dale Purves, George J Augustine, David Fitzpatrick, Lawrence C Katz, Anthony-Samuel LaMantia, James. Collectively, these data show that latent memory is induced in Aplysia by long-term sensitization training. This latent memory outlasts LTM expression by at least two days and is able to facilitate the induction of three temporally distinct phases of by: The cellular and molecular mechanisms contributing to memory storage in Aplysia have been studied most extensively for a simple withdrawal reflex of the gill and siphon (for review, see Hawkins, Mayford, & Kandel, ) (). Aplysia has an external respiratory organ - the gill - that is covered by a sheet of skin called the mantle shelf, which ends in a fleshy spout called the : Robert D. Hawkins.

Introduction. Memory and synaptic plasticity in many systems, including Aplysia and hippocampus, have different stages, which are defined primarily by their time courses but also involve different training protocols and different cellular and molecular mechanisms. Thus, relatively weak stimulation produces short-term plasticity, which lasts minutes and involves covalent modifications in either Cited by: 2. The marine snail Aplysia californica exhibits a simple defensive withdrawal reflex that can undergo several forms of learning. In particular, the reflex can exhibit long-term sensitization (LTS), a form of nonassociative memory. LTS is mediated by long-term facilitation (LTF) of the monosynaptic connection between the sensory and motor neurons that mediate the withdrawal : David L. Glanzman. Habituation can exhibit both short- and long-term forms. In Aplysia the siphon-elicited gill- and siphon-withdrawal reflex can undergo habituation that persists for several weeks (Carew et al., ).Cited by: Keep NS intact, cut away most of body, leave the siphon skin & tail still connected together and to the system.

Latent memory for sensitization in Aplysia. short-term, intermediate-term, and long-term memory. Under our training conditions, the latent memory persists for at least 2 d following the decay. A fundamental problem in neurobiology is to understand the basic processes that endow the nervous system with the ability to store and retrieve long-term memory. A related problem is to understand the relationship between the mechanisms for the induction, storage and retrieval of short-term memory and those for long-term by: 3. J. David Sweatt, in Mechanisms of Memory (Second Edition), Reaction Category 2—Generation of Long Half-Life Molecules. Aplysia long-term facilitation of neurotransmitter release provides an example of our second category of memory-forming chemical reaction: generation of long half-life signaling molecules. In this case, the duration of the memory subserved by this mechanism is. Sensitization of the gill- and siphon-withdrawal reflex in Aplysia is thought to result from a set of molecular processes with different time courses: short-term sensitization is explained by.